7L2F

Cryo-EM structure of NTD-directed neutralizing antibody 5-24 in complex with prefusion SARS-CoV-2 spike glycoprotein

7L2F の概要

• エントリーDOI: 10.2210/pdb7l2f/pdb
• EMDBエントリー: 23127
• 分子名称: Spike glycoprotein, 5-24 heavy chain, 5-24 light chain, ... (6 entities in total)
• 機能のキーワード: neutralizing antibody, fusion protein, spike glycoprotein, covid-19, ntd, ntd-directed antibody, 5-24, viral protein, immune system, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 590087.71

構造登録者

Cerutti, G.,Shapiro, L. (登録日: 2020-12-16, 公開日: 2021-03-24, 最終更新日: 2021-05-26)

• 主引用文献: Cerutti, G.,Guo, Y.,Zhou, T.,Gorman, J.,Lee, M.,Rapp, M.,Reddem, E.R.,Yu, J.,Bahna, F.,Bimela, J.,Huang, Y.,Katsamba, P.S.,Liu, L.,Nair, M.S.,Rawi, R.,Olia, A.S.,Wang, P.,Zhang, B.,Chuang, G.Y.,Ho, D.D.,Sheng, Z.,Kwong, P.D.,Shapiro, L.; Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite.; Cell Host Microbe, 29:819-, 2021; PubMed: 33789084; DOI: 10.1016/j.chom.2021.03.005

実験手法

ELECTRON MICROSCOPY (3.9 Å)