7L28

Crystal structure of the catalytic domain of human PDE3A bound to Trequinsin

7L28 の概要

• エントリーDOI: 10.2210/pdb7l28/pdb
• 分子名称: cGMP-inhibited 3',5'-cyclic phosphodiesterase A, (2E)-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-2,3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one, MANGANESE (II) ION, ... (6 entities in total)
• 機能のキーワード: hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 174851.59

構造登録者

Horner, S.W.,Garvie, C. (登録日: 2020-12-16, 公開日: 2021-06-16, 最終更新日: 2023-10-18)

• 主引用文献: Garvie, C.W.,Wu, X.,Papanastasiou, M.,Lee, S.,Fuller, J.,Schnitzler, G.R.,Horner, S.W.,Baker, A.,Zhang, T.,Mullahoo, J.P.,Westlake, L.,Hoyt, S.H.,Toetzl, M.,Ranaghan, M.J.,de Waal, L.,McGaunn, J.,Kaplan, B.,Piccioni, F.,Yang, X.,Lange, M.,Tersteegen, A.,Raymond, D.,Lewis, T.A.,Carr, S.A.,Cherniack, A.D.,Lemke, C.T.,Meyerson, M.,Greulich, H.; Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.; Nat Commun, 12:4375-4375, 2021; PubMed: 34272366; DOI: 10.1038/s41467-021-24495-w

実験手法

X-RAY DIFFRACTION (2.2 Å)