7L15

Marsupial T cell receptor Spl_118

7L15 の概要

• エントリーDOI: 10.2210/pdb7l15/pdb
• 分子名称: T cell receptor mu chain, T cell receptor gamma chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: t cell receptor, antigen recognition, igv domain, immune system
• 由来する生物種: Monodelphis domestica; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50874.21

構造登録者

Wegrecki, M.,Kannan Sivaraman, K.,Praveena, T.,Le Nours, J.,Rossjohn, J. (登録日: 2020-12-14, 公開日: 2021-03-24, 最終更新日: 2024-04-03)

主引用文献

Morrissey, K.A.,Wegrecki, M.,Praveena, T.,Hansen, V.L.,Bu, L.,Sivaraman, K.K.,Darko, S.,Douek, D.C.,Rossjohn, J.,Miller, R.D.,Le Nours, J.
The molecular assembly of the marsupial gamma mu T cell receptor defines a third T cell lineage.
Science, 371:1383-1388, 2021

PubMed Abstract: αβ and γδ T cell receptors (TCRs) are highly diverse antigen receptors that define two evolutionarily conserved T cell lineages. We describe a population of γμTCRs found exclusively in non-eutherian mammals that consist of a two-domain (Vγ-Cγ) γ-chain paired to a three-domain (Vμ-Vμj-Cμ) μ-chain. γμTCRs were characterized by restricted diversity in the Vγ and Vμj domains and a highly diverse unpaired Vμ domain. Crystal structures of two distinct γμTCRs revealed the structural basis of the association of the γμTCR heterodimer. The Vμ domain shared the characteristics of a single-domain antibody within which the hypervariable CDR3μ loop suggests a major antigen recognition determinant. We define here the molecular basis underpinning the assembly of a third TCR lineage, the γμTCR.

PubMed: 33766885
DOI: 10.1126/science.abe7070

実験手法

X-RAY DIFFRACTION (2.25 Å)