7KY0
Inactive conformation of EGFR (T790M/V948R) kinase in complex with BI-4020
Summary for 7KY0
| Entry DOI | 10.2210/pdb7ky0/pdb |
| Descriptor | Epidermal growth factor receptor, (20R)-10,15,20-trimethyl-2-[(4-methylpiperazin-1-yl)methyl]-18,19,20,21-tetrahydro-15H,17H-12,8-(metheno)pyrazolo[3',4':2,3][1,5,10,12]oxatriazacycloheptadecino[12,11-a]benzimidazol-7(6H)-one (2 entities in total) |
| Functional Keywords | egfr, kinase, inhibitor, macrocycle, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 153069.09 |
| Authors | Beyett, T.S.,Eck, M.J. (deposition date: 2020-12-06, release date: 2022-01-19, Last modification date: 2024-05-29) |
| Primary citation | Beyett, T.S.,Rana, J.K.,Schaeffner, I.K.,Heppner, D.E.,Eck, M.J. Structural Analysis of the Macrocyclic Inhibitor BI-4020 Binding to EGFR Kinase. Chemmedchem, :e202300343-e202300343, 2024 Cited by PubMed: 38523074DOI: 10.1002/cmdc.202300343 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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