7KY0

Inactive conformation of EGFR (T790M/V948R) kinase in complex with BI-4020

7KY0 の概要

• エントリーDOI: 10.2210/pdb7ky0/pdb
• 分子名称: Epidermal growth factor receptor, (20R)-10,15,20-trimethyl-2-[(4-methylpiperazin-1-yl)methyl]-18,19,20,21-tetrahydro-15H,17H-12,8-(metheno)pyrazolo[3',4':2,3][1,5,10,12]oxatriazacycloheptadecino[12,11-a]benzimidazol-7(6H)-one (2 entities in total)
• 機能のキーワード: egfr, kinase, inhibitor, macrocycle, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 153069.09

構造登録者

Beyett, T.S.,Eck, M.J. (登録日: 2020-12-06, 公開日: 2022-01-19, 最終更新日: 2024-05-29)

• 主引用文献: Beyett, T.S.,Rana, J.K.,Schaeffner, I.K.,Heppner, D.E.,Eck, M.J.; Structural Analysis of the Macrocyclic Inhibitor BI-4020 Binding to EGFR Kinase.; Chemmedchem, :e202300343-e202300343, 2024; PubMed: 38523074; DOI: 10.1002/cmdc.202300343

実験手法

X-RAY DIFFRACTION (3.1 Å)