7KWD

Crystal structure of Thermus thermophilus alkaline phosphatase

7KWD の概要

• エントリーDOI: 10.2210/pdb7kwd/pdb
• 分子名称: Alkaline phosphatase, L(+)-TARTARIC ACID, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: homodimeric enzyme, dephosphorylate compounds, hydrolase
• 由来する生物種: Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 110322.57

構造登録者

Gallo, G.,Coelho, C.,Borges, B.,Negri, N.,Maiello, F.,Hardy, L.,Wurtele, M. (登録日: 2020-11-30, 公開日: 2021-04-14, 最終更新日: 2023-10-18)

主引用文献

Borges, B.,Gallo, G.,Coelho, C.,Negri, N.,Maiello, F.,Hardy, L.,Wurtele, M.
Dynamic cross correlation analysis of Thermus thermophilus alkaline phosphatase and determinants of thermostability.
Biochim Biophys Acta Gen Subj, 1865:129895-129895, 2021

PubMed Abstract: Understanding the determinants of protein thermostability is very important both from the theoretical and applied perspective. One emerging view in thermostable enzymes seems to indicate that a salt bridge/charged residue network plays a fundamental role in their thermostability.

PubMed: 33781823
DOI: 10.1016/j.bbagen.2021.129895

実験手法

X-RAY DIFFRACTION (2.1 Å)