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7KVP

Human CYP3A4 bound to an inhibitor

Summary for 7KVP
Entry DOI10.2210/pdb7kvp/pdb
DescriptorCytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, tert-butyl [(2R)-1-(naphthalen-1-yl)-3-{[(2S)-1-oxo-3-phenyl-1-{[3-(pyridin-3-yl)propyl]amino}propan-2-yl]sulfanyl}propan-2-yl]carbamate, ... (4 entities in total)
Functional Keywordscyp3a4, inhibitor, complex, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight56958.08
Authors
Sevrioukova, I. (deposition date: 2020-11-28, release date: 2021-01-20, Last modification date: 2023-10-18)
Primary citationSamuels, E.R.,Sevrioukova, I.F.
Rational Design of CYP3A4 Inhibitors: A One-Atom Linker Elongation in Ritonavir-Like Compounds Leads to a Marked Improvement in the Binding Strength.
Int J Mol Sci, 22:-, 2021
Cited by
PubMed: 33467005
DOI: 10.3390/ijms22020852
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.75 Å)
Structure validation

220472

數據於2024-05-29公開中

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