7KSV

DNA Polymerase Mu, dGTP:Ct Product State Ternary Complex, 10 mM Mn2+ (960min)

Summary for 7KSV

• Entry DOI: 10.2210/pdb7ksv/pdb
• Descriptor: DNA-directed DNA/RNA polymerase mu, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA (5'-D(*CP*GP*GP*CP*CP*TP*AP*CP*G)-3'), ... (11 entities in total)
• Functional Keywords: time-lapse crystallography, oxidized nucleotide insertion, dna polymerase mu, double strand break repair, replication, replication-dna complex, replication/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 46830.96

Authors

Jamsen, J.A.,Wilson, S.H. (deposition date: 2020-11-24, release date: 2021-12-01, Last modification date: 2023-11-15)

• Primary citation: Jamsen, J.A.,Sassa, A.,Shock, D.D.,Beard, W.A.,Wilson, S.H.; Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide.; Nat Commun, 12:2059-2059, 2021; PubMed: 33824325; DOI: 10.1038/s41467-021-21354-6

Experimental method

X-RAY DIFFRACTION (1.64 Å)