7KSK
Thiophenyl-Pyrazolourea Derivatives as Potent, Brian Penetrant, Orally Bioavailable, and Isoform-Selective JNK3 Inhibitors
7KSK の概要
エントリーDOI | 10.2210/pdb7ksk/pdb |
分子名称 | Mitogen-activated protein kinase 10, 4-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(oxetan-3-yl)thiophene-2-carboxamide (3 entities in total) |
機能のキーワード | jnk3, kinase inhibitor, alzheimer disease, pyrazolourea, neurodegeneration, transferase, transferase-inhibitor complex, transferase/inhibitor |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 53067.20 |
構造登録者 | |
主引用文献 | Feng, Y.,Park, H.,Bauer, L.,Ryu, J.C.,Yoon, S.O. Thiophene-Pyrazolourea Derivatives as Potent, Orally Bioavailable, and Isoform-Selective JNK3 Inhibitors. Acs Med.Chem.Lett., 12:24-29, 2021 Cited by PubMed: 33488960DOI: 10.1021/acsmedchemlett.0c00533 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.84 Å) |
構造検証レポート
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