Loading
PDBj
メニューPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7KSK

Thiophenyl-Pyrazolourea Derivatives as Potent, Brian Penetrant, Orally Bioavailable, and Isoform-Selective JNK3 Inhibitors

7KSK の概要
エントリーDOI10.2210/pdb7ksk/pdb
分子名称Mitogen-activated protein kinase 10, 4-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(oxetan-3-yl)thiophene-2-carboxamide (3 entities in total)
機能のキーワードjnk3, kinase inhibitor, alzheimer disease, pyrazolourea, neurodegeneration, transferase, transferase-inhibitor complex, transferase/inhibitor
由来する生物種Homo sapiens (Human)
タンパク質・核酸の鎖数1
化学式量合計53067.20
構造登録者
Park, H. (登録日: 2020-11-23, 公開日: 2021-03-03, 最終更新日: 2023-10-18)
主引用文献Feng, Y.,Park, H.,Bauer, L.,Ryu, J.C.,Yoon, S.O.
Thiophene-Pyrazolourea Derivatives as Potent, Orally Bioavailable, and Isoform-Selective JNK3 Inhibitors.
Acs Med.Chem.Lett., 12:24-29, 2021
Cited by
PubMed: 33488960
DOI: 10.1021/acsmedchemlett.0c00533
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (1.84 Å)
構造検証レポート
Validation report summary of 7ksk
検証レポート(詳細版)ダウンロードをダウンロード

219869

件を2024-05-15に公開中

PDB statisticsPDBj update infoContact PDBjnumon