7KQI

Antibodies that engage the hemagglutinin receptor-binding site of influenza B viruses

Summary for 7KQI

• Entry DOI: 10.2210/pdb7kqi/pdb
• Descriptor: 1209 Fab heavy chain, 1209 Fab light chain, Hemagglutinin, ... (5 entities in total)
• Functional Keywords: influenza, antibody, receptor binding site, vaccine, b cell, immune system, immune system-viral protein complex, immune system/viral protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 83264.70

Authors

Bajic, G.,Harrison, S.C. (deposition date: 2020-11-16, release date: 2020-12-16, Last modification date: 2024-10-30)

Primary citation

Bajic, G.,Harrison, S.C.
Antibodies That Engage the Hemagglutinin Receptor-Binding Site of Influenza B Viruses.
Acs Infect Dis., 7:1-5, 2021

PubMed Abstract: We describe cross-reactive human antibodies recognizing influenza B viruses spanning nearly 80 years of antigenic drift. Structures show that they engage the receptor-binding site (RBS) of the viral hemagglutinin with strong similarities to their influenza A counterparts, despite structural differences between the RBS of influenza A and B. Our data show that these antibodies readily cross-react with both influenza B Victoria and Yamagata lineages. We also note that all antibodies are encoded by IGHV3-9/IGK1-33. Future research will provide insight into the prevalence of these antibodies in the human population.

PubMed: 33274930
DOI: 10.1021/acsinfecdis.0c00726

Experimental method

X-RAY DIFFRACTION (4.2 Å)