7KQI

Antibodies that engage the hemagglutinin receptor-binding site of influenza B viruses

7KQI の概要

• エントリーDOI: 10.2210/pdb7kqi/pdb
• 分子名称: 1209 Fab heavy chain, 1209 Fab light chain, Hemagglutinin, ... (5 entities in total)
• 機能のキーワード: influenza, antibody, receptor binding site, vaccine, b cell, immune system, immune system-viral protein complex, immune system/viral protein
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 83264.70

構造登録者

Bajic, G.,Harrison, S.C. (登録日: 2020-11-16, 公開日: 2020-12-16, 最終更新日: 2024-10-30)

主引用文献

Bajic, G.,Harrison, S.C.
Antibodies That Engage the Hemagglutinin Receptor-Binding Site of Influenza B Viruses.
Acs Infect Dis., 7:1-5, 2021

PubMed Abstract: We describe cross-reactive human antibodies recognizing influenza B viruses spanning nearly 80 years of antigenic drift. Structures show that they engage the receptor-binding site (RBS) of the viral hemagglutinin with strong similarities to their influenza A counterparts, despite structural differences between the RBS of influenza A and B. Our data show that these antibodies readily cross-react with both influenza B Victoria and Yamagata lineages. We also note that all antibodies are encoded by IGHV3-9/IGK1-33. Future research will provide insight into the prevalence of these antibodies in the human population.

PubMed: 33274930
DOI: 10.1021/acsinfecdis.0c00726

実験手法

X-RAY DIFFRACTION (4.2 Å)