7KP0

CD1a-42:1 SM binary complex

Summary for 7KP0

• Entry DOI: 10.2210/pdb7kp0/pdb
• Descriptor: T-cell surface glycoprotein CD1a, Beta-2-microglobulin, (4R,7S)-4-hydroxy-7-[(1S,2E)-1-hydroxyhexadec-2-en-1-yl]-N,N,N-trimethyl-4,9-dioxo-3,5-dioxa-8-aza-4lambda~5~-phosphadotriacontan-1-aminium, ... (5 entities in total)
• Functional Keywords: cd1, antigen presentation, lipid, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 45834.80

Authors

Wegrecki, M.,Le Nours, J.,Rossjohn, J. (deposition date: 2020-11-10, release date: 2021-05-05, Last modification date: 2023-10-18)

• Primary citation: Cotton, R.N.,Wegrecki, M.,Cheng, T.Y.,Chen, Y.L.,Veerapen, N.,Le Nours, J.,Orgill, D.P.,Pomahac, B.,Talbot, S.G.,Willis, R.,Altman, J.D.,de Jong, A.,Van Rhijn, I.,Clark, R.A.,Besra, G.S.,Ogg, G.,Rossjohn, J.,Moody, D.B.; CD1a selectively captures endogenous cellular lipids that broadly block T cell response.; J.Exp.Med., 218:-, 2021; PubMed: 33961028; DOI: 10.1084/jem.20202699

Experimental method

X-RAY DIFFRACTION (2.4 Å)