7KMD

Crystal structure of a HIV-1 clade C isolate Du172.17 HR1.R4.664 Env trimer in complex with human Fabs PGT124 and 35O22

Summary for 7KMD

• Entry DOI: 10.2210/pdb7kmd/pdb
• Descriptor: 35O22 Heavy chain, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (13 entities in total)
• Functional Keywords: hiv, envelope, glycoprotein, prefusion trimer, glycan, hiv-1 gp120, hiv-1 gp41, neutralizing antibodies, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 178552.65

Authors

Kumar, S.,Wilson, I.A. (deposition date: 2020-11-02, release date: 2021-07-07, Last modification date: 2023-10-18)

• Primary citation: Kumar, S.,Lin, X.,Ngo, T.,Shapero, B.,Sou, C.,Allen, J.D.,Copps, J.,Zhang, L.,Ozorowski, G.,He, L.,Crispin, M.,Ward, A.B.,Wilson, I.A.,Zhu, J.; Neutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles.; Mbio, 12:e0042921-e0042921, 2021; PubMed: 34156262; DOI: 10.1128/mBio.00429-21

Experimental method

X-RAY DIFFRACTION (3.39228580771 Å)