7KM8

Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001914, orthorhombic crystal from

Summary for 7KM8

• Entry DOI: 10.2210/pdb7km8/pdb
• Descriptor: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2S)-2-[(3-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3,3-difluoropropanoic acid, ... (5 entities in total)
• Functional Keywords: ssgcid, sddc, inhibitor, structural genomics, seattle structural genomics center for infectious disease, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Mycobacterium ulcerans (strain Agy99)
• Total number of polymer chains: 2
• Total formula weight: 40520.69

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2020-11-02, release date: 2021-07-07, Last modification date: 2023-10-18)

• Primary citation: Abendroth, J.,Dranow, D.M.,Lorimer, D.D.,Horanyi, P.S.,Edwards, T.E.; Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001914, orthorhombic crystal form; to be published,

Experimental method

X-RAY DIFFRACTION (1.55 Å)