7KM7

Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001914, tetragonal crystal from

7KM7 の概要

• エントリーDOI: 10.2210/pdb7km7/pdb
• 分子名称: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2S)-2-[(3-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3,3-difluoropropanoic acid, ... (5 entities in total)
• 機能のキーワード: ssgcid, sddc, inhibitor, structural genomics, seattle structural genomics center for infectious disease, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Mycobacterium ulcerans (strain Agy99)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20407.28

構造登録者

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2020-11-02, 公開日: 2021-07-07, 最終更新日: 2023-10-18)

• 主引用文献: Abendroth, J.,Dranow, D.M.,Lorimer, D.D.,Horanyi, P.S.,Edwards, T.E.; Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001914, tetragonal crystal form; to be published,

実験手法

X-RAY DIFFRACTION (1.8 Å)