7KKE

Phosphoinositide 3-Kinase gamma bound to a thiazole inhibitor

7KKE の概要

• エントリーDOI: 10.2210/pdb7kke/pdb
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, N-[2-(3,3-dimethylbutoxy)ethyl]-N'-{4-methyl-5-[(pyridin-4-yl)ethynyl]-1,3-thiazol-2-yl}urea (3 entities in total)
• 機能のキーワード: kinase, inhibitor, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 111655.27

構造登録者

Jacobs, M.D.,Griffith, J.P. (登録日: 2020-10-27, 公開日: 2021-03-24, 最終更新日: 2023-10-18)

• 主引用文献: Bandarage, U.K.,Aronov, A.M.,Cao, J.,Come, J.H.,Cottrell, K.M.,Davies, R.J.,Giroux, S.,Jacobs, M.,Mahajan, S.,Messersmith, D.,Moody, C.S.,Swett, R.,Xu, J.; Discovery of a Novel Series of Potent and Selective Alkynylthiazole-Derived PI3K gamma Inhibitors.; Acs Med.Chem.Lett., 12:129-135, 2021; PubMed: 33488974; DOI: 10.1021/acsmedchemlett.0c00573

実験手法

X-RAY DIFFRACTION (2.81 Å)