7KJ9

Wild-type epi-isozizaene synthase: complex with 3 Mg2+ and risedronate

7KJ9 の概要

• エントリーDOI: 10.2210/pdb7kj9/pdb
• 分子名称: epi-isozizaene synthase, MAGNESIUM ION, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: terpene cyclase, complex, bisphosphonate inhibitor, risedronate, lyase
• 由来する生物種: Streptomyces coelicolor
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44168.10

構造登録者

Ronnebaum, T.A.,Gardner, S.M.,Christianson, D.W. (登録日: 2020-10-26, 公開日: 2020-12-16, 最終更新日: 2023-10-18)

• 主引用文献: Ronnebaum, T.A.,Gardner, S.M.,Christianson, D.W.; An Aromatic Cluster in the Active Site of epi -Isozizaene Synthase Is an Electrostatic Toggle for Divergent Terpene Cyclization Pathways.; Biochemistry, 59:4744-4754, 2020; PubMed: 33270439; DOI: 10.1021/acs.biochem.0c00876

実験手法

X-RAY DIFFRACTION (2.2 Å)