7KIB

PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 4

7KIB の概要

• エントリーDOI: 10.2210/pdb7kib/pdb
• 分子名称: Protein arginine N-methyltransferase 5, Methylosome protein 50, (2R,3R,3aS,6S,6aR)-6-[(2-amino-3-bromoquinolin-7-yl)oxy]-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydro-3aH-cyclopenta[b]furan-3,3a-diol, ... (7 entities in total)
• 機能のキーワード: transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 113078.65

構造登録者

Palte, R.L.,Hayes, R.P. (登録日: 2020-10-23, 公開日: 2021-04-21, 最終更新日: 2023-10-18)

• 主引用文献: Quiroz, R.V.,Reutershan, M.H.,Schneider, S.E.,Sloman, D.,Lacey, B.M.,Swalm, B.M.,Yeung, C.S.,Gibeau, C.,Spellman, D.S.,Rankic, D.A.,Chen, D.,Witter, D.,Linn, D.,Munsell, E.,Feng, G.,Xu, H.,Hughes, J.M.E.,Lim, J.,Sauri, J.,Geddes, K.,Wan, M.,Mansueto, M.S.,Follmer, N.E.,Fier, P.S.,Siliphaivanh, P.,Daublain, P.,Palte, R.L.,Hayes, R.P.,Lee, S.,Kawamura, S.,Silverman, S.,Sanyal, S.,Henderson, T.J.,Ye, Y.,Gao, Y.,Nicholson, B.,Machacek, M.R.; The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer.; J.Med.Chem., 64:3911-3939, 2021; PubMed: 33755451; DOI: 10.1021/acs.jmedchem.0c02083

実験手法

X-RAY DIFFRACTION (2.52 Å)