7KI8

Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001580

7KI8 の概要

• エントリーDOI: 10.2210/pdb7ki8/pdb
• 分子名称: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1-[2-({3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propyl}amino)phenyl]piperidine-4-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: ssgcid, sddc, inhibitor, structural genomics, seattle structural genomics center for infectious disease, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Mycobacterium ulcerans (strain Agy99)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20193.52

構造登録者

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2020-10-23, 公開日: 2021-07-07, 最終更新日: 2023-10-18)

• 主引用文献: Abendroth, J.A.,Dranow, D.M.,Zigweid, R.M.,Lorimer, D.D.,Horanyi, P.S.,Edwards, T.E.; Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001580; to be published,

実験手法

X-RAY DIFFRACTION (1.25 Å)