7KI0

Semaglutide-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in Complex with Gs protein

7KI0 の概要

• エントリーDOI: 10.2210/pdb7ki0/pdb
• EMDBエントリー: 22882
• 分子名称: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (8 entities in total)
• 機能のキーワード: glucagon-like peptide-1 (glp-1) receptor semaglutide cryoem, membrane protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 163832.55

構造登録者

Zhang, X.,Belousoff, M.J.,Danev, R.,Sexton, P.M.,Wootten, D. (登録日: 2020-10-22, 公開日: 2021-08-04)

• 主引用文献: Zhang, X.,Belousoff, M.J.,Liang, Y.L.,Danev, R.,Sexton, P.M.,Wootten, D.; Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes.; Cell Rep, 36:109374-109374, 2021; PubMed: 34260945; DOI: 10.1016/j.celrep.2021.109374

実験手法

ELECTRON MICROSCOPY (2.5 Å)