7KH7
Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase in complex with Mg2+, NADPH, and NSC116565
Summary for 7KH7
Entry DOI | 10.2210/pdb7kh7/pdb |
Descriptor | Ketol-acid reductoisomerase (NADP(+)), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total) |
Functional Keywords | reductoisomerase, inhibitor, complex, metal binding protein, isomerase, isomerase-inhibitor complex, isomerase/inhibitor |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 2 |
Total formula weight | 77782.01 |
Authors | Kurz, J.L.,Patel, K.P.,Guddat, L.W. (deposition date: 2020-10-20, release date: 2021-07-14, Last modification date: 2023-10-18) |
Primary citation | Lin, X.,Kurz, J.L.,Patel, K.M.,Wun, S.J.,Hussein, W.M.,Lonhienne, T.,West, N.P.,McGeary, R.P.,Schenk, G.,Guddat, L.W. Discovery of a Pyrimidinedione Derivative with Potent Inhibitory Activity against Mycobacterium tuberculosis Ketol-Acid Reductoisomerase. Chemistry, 27:3130-3141, 2021 Cited by PubMed: 33215746DOI: 10.1002/chem.202004665 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.63 Å) |
Structure validation
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