7KE2

Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase in complex with Mg2+ and NSC116565

7KE2 の概要

• エントリーDOI: 10.2210/pdb7ke2/pdb
• 分子名称: Ketol-acid reductoisomerase (NADP(+)), MAGNESIUM ION, 6-hydroxy-2-methyl[1,3]thiazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione, ... (4 entities in total)
• 機能のキーワード: reductoisomerase, inhibitor, metal binding protein, isomerase, oxidoreductase
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 76268.88

構造登録者

Kurz, J.L.,Patel, K.P.,Guddat, L.W. (登録日: 2020-10-09, 公開日: 2021-07-14, 最終更新日: 2023-10-18)

• 主引用文献: Lin, X.,Kurz, J.L.,Patel, K.M.,Wun, S.J.,Hussein, W.M.,Lonhienne, T.,West, N.P.,McGeary, R.P.,Schenk, G.,Guddat, L.W.; Discovery of a Pyrimidinedione Derivative with Potent Inhibitory Activity against Mycobacterium tuberculosis Ketol-Acid Reductoisomerase.; Chemistry, 27:3130-3141, 2021; PubMed: 33215746; DOI: 10.1002/chem.202004665

実験手法

X-RAY DIFFRACTION (2.59 Å)