7KDB

Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor compound 35

7KDB の概要

• エントリーDOI: 10.2210/pdb7kdb/pdb
• 関連するPDBエントリー: 7KCC 7KCE 7KCF 7KDA
• 分子名称: S-adenosylmethionine synthase isoform type-2, 6-(4-hydroxyphenyl)-2,3-diphenyl-5-[(1H-pyrazol-3-yl)amino]pyrazolo[1,5-a]pyrimidin-7(4H)-one, CHLORIDE ION, ... (8 entities in total)
• 機能のキーワード: ethionine adenosyltransferase, sam, allosteric inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45137.97

構造登録者

Padyana, A.,Jin, L. (登録日: 2020-10-08, 公開日: 2021-04-21, 最終更新日: 2023-10-18)

• 主引用文献: Konteatis, Z.,Travins, J.,Gross, S.,Marjon, K.,Barnett, A.,Mandley, E.,Nicolay, B.,Nagaraja, R.,Chen, Y.,Sun, Y.,Liu, Z.,Yu, J.,Ye, Z.,Jiang, F.,Wei, W.,Fang, C.,Gao, Y.,Kalev, P.,Hyer, M.L.,DeLaBarre, B.,Jin, L.,Padyana, A.K.,Dang, L.,Murtie, J.,Biller, S.A.,Sui, Z.,Marks, K.M.; Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.; J.Med.Chem., 64:4430-4449, 2021; PubMed: 33829783; DOI: 10.1021/acs.jmedchem.0c01895

実験手法

X-RAY DIFFRACTION (1.24 Å)