7KCY

Crystal structure of S. aureus penicillin-binding protein 4 (PBP4) with cefoxitin

7KCY の概要

• エントリーDOI: 10.2210/pdb7kcy/pdb
• 分子名称: Penicillin-binding protein 4, (2R)-2-{(1S)-1-methoxy-2-oxo-1-[(thiophen-2-ylacetyl)amino]ethyl}-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: acyl-enzyme intermediate, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Staphylococcus aureus (strain COL)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41624.28

構造登録者

Alexander, J.A.N.,Strynadka, N.C.J. (登録日: 2020-10-07, 公開日: 2021-06-30, 最終更新日: 2023-10-18)

• 主引用文献: Satishkumar, N.,Alexander, J.A.N.,Poon, R.,Buggeln, E.,Argudin, M.A.,Strynadka, N.C.J.,Chatterjee, S.S.; PBP4-mediated beta-lactam resistance among clinical strains of Staphylococcus aureus.; J.Antimicrob.Chemother., 76:2268-2272, 2021; PubMed: 34151961; DOI: 10.1093/jac/dkab201

実験手法

X-RAY DIFFRACTION (1.85 Å)