7KCN

Reconstructed ancestor of HIUases and Transthyretins

Summary for 7KCN

• Entry DOI: 10.2210/pdb7kcn/pdb
• Related: 7KJJ
• Descriptor: HIUase-TTR ancestor, 1,2-ETHANEDIOL, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: unknown function, probably a 5-hydroxyisourate hydrolase
• Biological source: synthetic construct
• Total number of polymer chains: 2
• Total formula weight: 27990.21

Authors

Nagem, R.A.P.,Bleicher, L.,Costa, M.A.F. (deposition date: 2020-10-06, release date: 2021-05-19, Last modification date: 2024-05-22)

• Primary citation: Carrijo de Oliveira, L.,Figueiredo Costa, M.A.,Goncalves Pedersolli, N.,Heleno Batista, F.A.,Migliorini Figueira, A.C.,Salgado Ferreira, R.,Alves Pinto Nagem, R.,Alves Nahum, L.,Bleicher, L.; Reenacting the Birth of a Function: Functional Divergence of HIUases and Transthyretins as Inferred by Evolutionary and Biophysical Studies.; J.Mol.Evol., 89:370-383, 2021; PubMed: 33956179; DOI: 10.1007/s00239-021-10010-8

Experimental method

X-RAY DIFFRACTION (1.46 Å)