7KB6
Co-crystal structure of alpha glucosidase with compound 7
Summary for 7KB6
Entry DOI | 10.2210/pdb7kb6/pdb |
Descriptor | Isoform 2 of Neutral alpha-glucosidase AB, Glucosidase 2 subunit beta, TRIETHYLENE GLYCOL, ... (10 entities in total) |
Functional Keywords | alpha glucosidase ii, endoplasmic reticulum, hydrolase, inhibitor complex |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 4 |
Total formula weight | 354045.75 |
Authors | Karade, S.S.,Mariuzza, R.A. (deposition date: 2020-10-01, release date: 2021-10-06, Last modification date: 2023-10-18) |
Primary citation | Karade, S.S.,Hill, M.L.,Kiappes, J.L.,Manne, R.,Aakula, B.,Zitzmann, N.,Warfield, K.L.,Treston, A.M.,Mariuzza, R.A. N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum alpha-Glucosidases I and II with Antiviral Activity. J.Med.Chem., 64:18010-18024, 2021 Cited by PubMed: 34870992DOI: 10.1021/acs.jmedchem.1c01377 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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