7K9O

Co-crystal structure of alpha glucosidase with compound 3

7K9O の概要

• エントリーDOI: 10.2210/pdb7k9o/pdb
• 分子名称: Alpha glucosidase 2 alpha neutral subunit, Glucosidase 2 subunit beta, (1~{S},2~{S},3~{R},4~{S},5~{S})-1-(hydroxymethyl)-5-[6-[[2-[oxidanyl(oxidanylidene)-$l^{4}-azanyl]-4-(1,2,3,4-tetrazol-1-yl)phenyl]amino]hexylamino]cyclohexane-1,2,3,4-tetrol, ... (9 entities in total)
• 機能のキーワード: alpha glucosidase ii, endoplasmic reticulum, hydrolase, inhibitor complex
• 由来する生物種: Mus musculus (Mouse); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 347981.32

構造登録者

Karade, S.S.,Mariuzza, R.A. (登録日: 2020-09-29, 公開日: 2021-09-29, 最終更新日: 2023-10-18)

• 主引用文献: Karade, S.S.,Hill, M.L.,Kiappes, J.L.,Manne, R.,Aakula, B.,Zitzmann, N.,Warfield, K.L.,Treston, A.M.,Mariuzza, R.A.; N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum alpha-Glucosidases I and II with Antiviral Activity.; J.Med.Chem., 64:18010-18024, 2021; PubMed: 34870992; DOI: 10.1021/acs.jmedchem.1c01377

実験手法

X-RAY DIFFRACTION (2.302 Å)