7K89

Crystal structure of bovine RPE65 in complex with 4-fluoro-emixustat and palmitate

Summary for 7K89

Entry DOI	10.2210/pdb7k89/pdb
Descriptor	Retinoid isomerohydrolase, FE (II) ION, PALMITIC ACID, ... (7 entities in total)
Functional Keywords	non-heme iron, isomerohydrolase, inhibitor, beta-propeller, isomerase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Bos taurus (Bovine)
Total number of polymer chains	2
Total formula weight	123491.78
Authors	Kiser, P.D. (deposition date: 2020-09-26, release date: 2021-06-02, Last modification date: 2023-10-18)
Primary citation	Blum, E.,Zhang, J.,Zaluski, J.,Einstein, D.E.,Korshin, E.E.,Kubas, A.,Gruzman, A.,Tochtrop, G.P.,Kiser, P.D.,Palczewski, K. Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. J.Med.Chem., 64:8287-8302, 2021 Cited by PubMed: 34081480 DOI: 10.1021/acs.jmedchem.1c00279 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation