7K6U

Carbonic Anhydrase IX mimic complexed with 4-(2-(3-(4-methylphenyl)ureido)ethylsulfonamido)benzenesulfonamide

7K6U の概要

• エントリーDOI: 10.2210/pdb7k6u/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, 4-{[(2-{[(4-methylphenyl)carbamoyl]amino}ethyl)sulfonyl]amino}benzene-1-sulfonamide, ... (5 entities in total)
• 機能のキーワード: carbonic anhydrase, caii, caix inhibitor, structure guided drug design, structure activity relationship study, breast cancer, lyase, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29756.91

構造登録者

Andring, J.T.,Singh, S.,McKenna, R. (登録日: 2020-09-21, 公開日: 2020-12-23, 最終更新日: 2023-10-18)

• 主引用文献: Akgul, O.,Singh, S.,Andring, J.T.,McKenna, R.,Selleri, S.,Carta, F.,Angeli, A.,Supuran, C.T.; Handling drug-target selectivity: A study on ureido containing Carbonic Anhydrase inhibitors.; Eur.J.Med.Chem., 212:113035-113035, 2021; PubMed: 33303238; DOI: 10.1016/j.ejmech.2020.113035

実験手法

X-RAY DIFFRACTION (1.605 Å)