7K5V

OXA-48 bound by Compound 3.1

Summary for 7K5V

• Entry DOI: 10.2210/pdb7k5v/pdb
• Descriptor: Beta-lactamase, NAPHTHALENE-2,6-DISULFONIC ACID, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: beta-lactamase, carbapenemase, beta-lactamase inhibitor, complex, oxacillinase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 2
• Total formula weight: 57356.18

Authors

Taylor, D.M.,Hu, L.,Prasad, B.V.V.,Palzkill, T. (deposition date: 2020-09-17, release date: 2021-12-01, Last modification date: 2023-11-15)

• Primary citation: Taylor, D.M.,Anglin, J.,Hu, L.,Wang, L.,Sankaran, B.,Wang, J.,Matzuk, M.M.,Prasad, B.V.V.,Palzkill, T.; Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48.; Acs Infect Dis., 7:3345-3354, 2021; PubMed: 34817169; DOI: 10.1021/acsinfecdis.1c00501

Experimental method

X-RAY DIFFRACTION (2.8 Å)