7K5M

CRYSTAL STRUCTURE OF HBV CAPSID Y132A MUTANT IN COMPLEX WITH N-(3-chloro-4-fluorophenyl)-3-phenyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide AT 2.65A RESOLUTION

7K5M の概要

• エントリーDOI: 10.2210/pdb7k5m/pdb
• 分子名称: Capsid protein, N-(3-chloro-4-fluorophenyl)-3-phenyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide, ISOPROPYL ALCOHOL, ... (4 entities in total)
• 機能のキーワード: hvb capsid, viral protein
• 由来する生物種: Hepatitis B virus genotype D subtype adw (isolate United Kingdom/adyw/1979) (HBV-D)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 109423.32

構造登録者

Kuduk, S.D.,Stoops, B.,Alexander, R.,Lam, A.M.,Espiritu, C.,Vogel, R.,Lau, V.,Klumpp, K.,Flores, O.A.,Hartman, G.D.,Lukacs, C.M.,Abendroth, J. (登録日: 2020-09-17, 公開日: 2021-07-28, 最終更新日: 2024-04-03)

• 主引用文献: Kuduk, S.D.,Stoops, B.,Alexander, R.,Lam, A.M.,Espiritu, C.,Vogel, R.,Lau, V.,Klumpp, K.,Flores, O.A.,Hartman, G.D.; Identification of a new class of HBV capsid assembly modulator.; Bioorg.Med.Chem.Lett., 39:127848-127848, 2021; PubMed: 33610748; DOI: 10.1016/j.bmcl.2021.127848

実験手法

X-RAY DIFFRACTION (2.65 Å)