7K4I

Human Arginase 1 in complex with compound 06.

7K4I の概要

• エントリーDOI: 10.2210/pdb7k4i/pdb
• 分子名称: Arginase-1, MANGANESE (II) ION, 3-[(1~{S},2~{S},5~{R})-2-carboxy-6-thia-3-azabicyclo[3.2.0]heptan-1-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boranuide, ... (4 entities in total)
• 機能のキーワード: arginase, hydrolase, arginine, urea cycle, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 210911.20

構造登録者

Palte, R.L. (登録日: 2020-09-15, 公開日: 2021-10-06, 最終更新日: 2023-10-18)

• 主引用文献: Li, D.,Zhang, H.,Lyons, T.W.,Lu, M.,Achab, A.,Pu, Q.,Childers, M.,Mitcheltree, M.J.,Wang, J.,Martinot, T.A.,McMinn, S.E.,Sloman, D.L.,Palani, A.,Beard, A.,Nogle, L.,Gathiaka, S.,Sauri, J.,Kim, H.Y.,Adpressa, D.,Spacciapoli, P.,Miller, J.R.,Palte, R.L.,Lesburg, C.A.,Cumming, J.,Fischer, C.; Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors.; Acs Med.Chem.Lett., 12:1678-1688, 2021; PubMed: 34795856; DOI: 10.1021/acsmedchemlett.1c00258

実験手法

X-RAY DIFFRACTION (1.98 Å)