7K3D
The structure of NTMT1 in complex with compound DC1-13
Summary for 7K3D
Entry DOI | 10.2210/pdb7k3d/pdb |
Descriptor | N-terminal Xaa-Pro-Lys N-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, N~2~-{(2S)-1-[(naphthalen-1-yl)acetyl]-2,5-dihydro-1H-pyrrole-2-carbonyl}-L-lysyl-L-argininamide, ... (4 entities in total) |
Functional Keywords | methyltransferase, enzyme, inhibitor complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 56538.33 |
Authors | Chen, D.,Huang, R.,Noinaj, N. (deposition date: 2020-09-11, release date: 2021-04-14, Last modification date: 2023-10-18) |
Primary citation | Chen, D.,Dong, G.,Deng, Y.,Noinaj, N.,Huang, R. Structure-based Discovery of Cell-Potent Peptidomimetic Inhibitors for Protein N-Terminal Methyltransferase 1. Acs Med.Chem.Lett., 12:485-493, 2021 Cited by PubMed: 33738076DOI: 10.1021/acsmedchemlett.1c00012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.34 Å) |
Structure validation
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