7K3D

The structure of NTMT1 in complex with compound DC1-13

7K3D の概要

• エントリーDOI: 10.2210/pdb7k3d/pdb
• 分子名称: N-terminal Xaa-Pro-Lys N-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, N~2~-{(2S)-1-[(naphthalen-1-yl)acetyl]-2,5-dihydro-1H-pyrrole-2-carbonyl}-L-lysyl-L-argininamide, ... (4 entities in total)
• 機能のキーワード: methyltransferase, enzyme, inhibitor complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 56538.33

構造登録者

Chen, D.,Huang, R.,Noinaj, N. (登録日: 2020-09-11, 公開日: 2021-04-14, 最終更新日: 2023-10-18)

• 主引用文献: Chen, D.,Dong, G.,Deng, Y.,Noinaj, N.,Huang, R.; Structure-based Discovery of Cell-Potent Peptidomimetic Inhibitors for Protein N-Terminal Methyltransferase 1.; Acs Med.Chem.Lett., 12:485-493, 2021; PubMed: 33738076; DOI: 10.1021/acsmedchemlett.1c00012

実験手法

X-RAY DIFFRACTION (2.34 Å)