7K2N
Kelch domain of human KEAP1 bound to Nrf2-based cyclic peptide, c[BAL-DEETGE]
Summary for 7K2N
Entry DOI | 10.2210/pdb7k2n/pdb |
Descriptor | Kelch-like ECH-associated protein 1, (BAL)DPETGE, SULFATE ION, ... (4 entities in total) |
Functional Keywords | peptide inhibitor, inhibitor complex, loop-mimic, protein binding, cyclic peptide, protein binding-inhibitor complex, protein binding/inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 67153.81 |
Authors | Muellers, S.N.,Allen, K.N. (deposition date: 2020-09-08, release date: 2021-04-07, Last modification date: 2023-10-18) |
Primary citation | Ortet, P.C.,Muellers, S.N.,Viarengo-Baker, L.A.,Streu, K.,Szymczyna, B.R.,Beeler, A.B.,Allen, K.N.,Whitty, A. Recapitulating the Binding Affinity of Nrf2 for KEAP1 in a Cyclic Heptapeptide, Guided by NMR, X-ray Crystallography, and Machine Learning. J.Am.Chem.Soc., 143:3779-3793, 2021 Cited by PubMed: 33683866DOI: 10.1021/jacs.0c09799 PDB entries with the same primary citation |
Experimental method |
Structure validation
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