7K2A

Kelch domain of human KEAP1 bound to Nrf2 peptide, LDEETGEFA

7K2A の概要

• エントリーDOI: 10.2210/pdb7k2a/pdb
• 分子名称: Kelch-like ECH-associated protein 1, ACE-LEU-ASP-GLU-GLU-THR-GLY-GLU-PHE-ALA-NH2 (3 entities in total)
• 機能のキーワード: peptide inhibitor, inhibitor complex, loop-mimic, protein binding, protein binding-inhibitor complex, protein binding/inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 67045.92

構造登録者

Muellers, S.N.,Allen, K.N. (登録日: 2020-09-08, 公開日: 2021-04-07, 最終更新日: 2023-10-18)

• 主引用文献: Ortet, P.C.,Muellers, S.N.,Viarengo-Baker, L.A.,Streu, K.,Szymczyna, B.R.,Beeler, A.B.,Allen, K.N.,Whitty, A.; Recapitulating the Binding Affinity of Nrf2 for KEAP1 in a Cyclic Heptapeptide, Guided by NMR, X-ray Crystallography, and Machine Learning.; J.Am.Chem.Soc., 143:3779-3793, 2021; PubMed: 33683866; DOI: 10.1021/jacs.0c09799

実験手法

X-RAY DIFFRACTION (1.9 Å)