7K0X

Marsupial T cell receptor Spl_145

Summary for 7K0X

• Entry DOI: 10.2210/pdb7k0x/pdb
• Descriptor: T cell receptor mu chain, T cell receptor gamma chain, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: t cell receptor, antigen recognition, igv domain, immune system
• Biological source: Monodelphis domestica; More
• Total number of polymer chains: 4
• Total formula weight: 129880.86

Authors

Wegrecki, M.,Kannan Sivaraman, K.,Le Nours, J.,Rossjohn, J. (deposition date: 2020-09-06, release date: 2021-03-24, Last modification date: 2024-04-03)

Primary citation

Morrissey, K.A.,Wegrecki, M.,Praveena, T.,Hansen, V.L.,Bu, L.,Sivaraman, K.K.,Darko, S.,Douek, D.C.,Rossjohn, J.,Miller, R.D.,Le Nours, J.
The molecular assembly of the marsupial gamma mu T cell receptor defines a third T cell lineage.
Science, 371:1383-1388, 2021

PubMed Abstract: αβ and γδ T cell receptors (TCRs) are highly diverse antigen receptors that define two evolutionarily conserved T cell lineages. We describe a population of γμTCRs found exclusively in non-eutherian mammals that consist of a two-domain (Vγ-Cγ) γ-chain paired to a three-domain (Vμ-Vμj-Cμ) μ-chain. γμTCRs were characterized by restricted diversity in the Vγ and Vμj domains and a highly diverse unpaired Vμ domain. Crystal structures of two distinct γμTCRs revealed the structural basis of the association of the γμTCR heterodimer. The Vμ domain shared the characteristics of a single-domain antibody within which the hypervariable CDR3μ loop suggests a major antigen recognition determinant. We define here the molecular basis underpinning the assembly of a third TCR lineage, the γμTCR.

PubMed: 33766885
DOI: 10.1126/science.abe7070

Experimental method

X-RAY DIFFRACTION (3.1 Å)