7K0H

1.70 A resolution structure of SARS-CoV 3CL protease in complex with a deuterated GC376 alpha-ketoamide analog (compound 5)

7K0H の概要

• エントリーDOI: 10.2210/pdb7k0h/pdb
• 分子名称: Replicase polyprotein 1a, CHLORIDE ION, N-{(2S,3R)-4-(benzylamino)-3-hydroxy-4-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}-N~2~-[(benzyloxy)carbonyl]-L-leucinamide, ... (5 entities in total)
• 機能のキーワード: protease, severe acute respiratory syndrome coronavirus, sars 3cl protease inhhibitors, hydrolase, deuterated hydrolase inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human SARS coronavirus (SARS-CoV)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70263.00

構造登録者

Lovell, S.,Kashipathy, M.M.,Battaile, K.P.,Chamandi, S.D.,Nguyen, H.N.,Kim, Y.,Chang, K.O.,Groutas, W.C. (登録日: 2020-09-04, 公開日: 2021-07-07, 最終更新日: 2023-10-18)

• 主引用文献: Dampalla, C.S.,Zheng, J.,Perera, K.D.,Wong, L.R.,Meyerholz, D.K.,Nguyen, H.N.,Kashipathy, M.M.,Battaile, K.P.,Lovell, S.,Kim, Y.,Perlman, S.,Groutas, W.C.,Chang, K.O.; Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 34210738; DOI: 10.1073/pnas.2101555118

実験手法

X-RAY DIFFRACTION (1.7 Å)