7K0E

1.90 A resolution structure of SARS-CoV-2 3CL protease in complex with deuterated GC376

7K0E の概要

• エントリーDOI: 10.2210/pdb7k0e/pdb
• 分子名称: 3C-like proteinase, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, TETRAETHYLENE GLYCOL, ... (4 entities in total)
• 機能のキーワード: covid-19, protease, severe acute respiratory syndrome coronavirus 2, sars-cov-2 3cl protease inhhibitors, hydrolase, deuterated hydrolase inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69302.94

構造登録者

Lovell, S.,Kashipathy, M.M.,Battaile, K.P.,Chamandi, S.D.,Nguyen, H.N.,Kim, Y.,Chang, K.O.,Groutas, W.C. (登録日: 2020-09-04, 公開日: 2021-07-07, 最終更新日: 2023-10-18)

• 主引用文献: Dampalla, C.S.,Zheng, J.,Perera, K.D.,Wong, L.R.,Meyerholz, D.K.,Nguyen, H.N.,Kashipathy, M.M.,Battaile, K.P.,Lovell, S.,Kim, Y.,Perlman, S.,Groutas, W.C.,Chang, K.O.; Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 34210738; DOI: 10.1073/pnas.2101555118

実験手法

X-RAY DIFFRACTION (1.9 Å)