7JXZ

Structure of HbA with compound (S)-4

Summary for 7JXZ

• Entry DOI: 10.2210/pdb7jxz/pdb
• Descriptor: Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE, ... (8 entities in total)
• Functional Keywords: hemoglobin, oxygen transport
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 66829.56

Authors

Jasti, J. (deposition date: 2020-08-28, release date: 2021-01-13, Last modification date: 2023-10-18)

• Primary citation: Gopalsamy, A.,Aulabaugh, A.E.,Barakat, A.,Beaumont, K.C.,Cabral, S.,Canterbury, D.P.,Casimiro-Garcia, A.,Chang, J.S.,Chen, M.Z.,Choi, C.,Dow, R.L.,Fadeyi, O.O.,Feng, X.,France, S.P.,Howard, R.M.,Janz, J.M.,Jasti, J.,Jasuja, R.,Jones, L.H.,King-Ahmad, A.,Knee, K.M.,Kohrt, J.T.,Limberakis, C.,Liras, S.,Martinez, C.A.,McClure, K.F.,Narayanan, A.,Narula, J.,Novak, J.J.,O'Connell, T.N.,Parikh, M.D.,Piotrowski, D.W.,Plotnikova, O.,Robinson, R.P.,Sahasrabudhe, P.V.,Sharma, R.,Thuma, B.A.,Vasa, D.,Wei, L.,Wenzel, A.Z.,Withka, J.M.,Xiao, J.,Yayla, H.G.; PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease.; J.Med.Chem., 64:326-342, 2021; PubMed: 33356244; DOI: 10.1021/acs.jmedchem.0c01518

Experimental method

X-RAY DIFFRACTION (2.23 Å)