7JKQ
Human DPP9-CARD8 complex
Summary for 7JKQ
Entry DOI | 10.2210/pdb7jkq/pdb |
EMDB information | 22367 22974 |
Descriptor | Dipeptidyl peptidase 9, Caspase recruitment domain-containing protein 8 (2 entities in total) |
Functional Keywords | card8, dpp9, inflammasome, val-boropro (vbp), talabostat, innate immunity, immune system, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 318202.39 |
Authors | Sharif, H.,Hollingsworth, L.R. (deposition date: 2020-07-28, release date: 2021-05-26, Last modification date: 2024-03-06) |
Primary citation | Sharif, H.,Hollingsworth, L.R.,Griswold, A.R.,Hsiao, J.C.,Wang, Q.,Bachovchin, D.A.,Wu, H. Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment. Immunity, 54:1392-, 2021 Cited by PubMed: 34019797DOI: 10.1016/j.immuni.2021.04.024 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.3 Å) |
Structure validation
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