7I3G

Group deposition of Coxsackievirus A16 (G-10) 2A protease in complex with inhibitors from the ASAP AViDD centre -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with ASAP-0035396-001 (A71EV2A-x4426)

This is a non-PDB format compatible entry.

Summary for 7I3G

• Entry DOI: 10.2210/pdb7i3g/pdb
• Group deposition: Group deposition of Coxsackievirus A16 (G-10) 2A protease in complex with inhibitors from the ASAP AViDD centre (G_1002344)
• Descriptor: Protease 2A, (1R)-1-(1-methyl-1H-indazol-3-yl)-N-[2-(1,3-oxazol-4-yl)ethyl]prop-2-yn-1-amine, ZINC ION, ... (5 entities in total)
• Functional Keywords: diamond light source, i04-1, asap, a71 2a, enterovirus, protease, crystallographic fragment screening, pandda, pandda2, xchemexplorer, viral protein
• Biological source: Coxsackievirus A16
• Total number of polymer chains: 1
• Total formula weight: 16394.73

Authors

Lithgo, R.M.,Fairhead, M.,Koekemoer, L.,Balcomb, B.H.,Capkin, E.,Chandran, A.V.,Golding, M.,Godoy, A.S.,Aschenbrenner, J.C.,Marples, P.G.,Ni, X.,Thompson, W.,Tomlinson, C.W.E.,Wild, C.,Winokan, M.,Xavier, M.-A.E.,Kenton, N.,Tucker, J.,DiPoto, M.,Lee, A.,Fearon, D.,von Delft, F. (deposition date: 2025-03-12, release date: 2025-04-02, Last modification date: 2025-04-09)

• Primary citation: Lithgo, R.M.,Fairhead, M.,Koekemoer, L.,Balcomb, B.H.,Capkin, E.,Chandran, A.V.,Golding, M.,Godoy, A.S.,Aschenbrenner, J.C.,Marples, P.G.,Ni, X.,Thompson, W.,Tomlinson, C.W.E.,Wild, C.,Winokan, M.,Xavier, M.-A.E.,Kenton, N.,Tucker, J.,DiPoto, M.,Lee, A.,Fearon, D.,von Delft, F.; Group deposition of Coxsackievirus A16 (G-10) 2A protease in complex with inhibitors from the ASAP AViDD centre; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.62 Å)