7GTK
PanDDA Analysis group deposition -- Crystal structure of PTP1B in complex with FMOOA000552a
This is a non-PDB format compatible entry.
Summary for 7GTK
Entry DOI | 10.2210/pdb7gtk/pdb |
Group deposition | PanDDA Analysis group deposition (G_1002284) |
Descriptor | Tyrosine-protein phosphatase non-receptor type 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, (4R)-2-(2-hydroxyethyl)-4-methoxy-3,4-dihydro-1lambda~6~,2-benzothiazine-1,1(2H)-dione, ... (4 entities in total) |
Functional Keywords | pandda, diamond i04-1 fragment screening, protein tyrosine phosphatase, ptp, protein tyrosine phosphatase 1b, ptp1b, enzyme, allostery, multiconformer, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 37725.01 |
Authors | Mehlman, T.,Ginn, H.M.,Keedy, D.A. (deposition date: 2024-01-03, release date: 2024-01-24, Last modification date: 2024-04-24) |
Primary citation | Mehlman, T.S.,Ginn, H.M.,Keedy, D.A. An expanded view of ligandability in the allosteric enzyme PTP1B from computational reanalysis of large-scale crystallographic data. Biorxiv, 2024 Cited by PubMed: 38260327DOI: 10.1101/2024.01.05.574428 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
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