7GTB

PanDDA Analysis group deposition -- Crystal structure of PTP1B in complex with FMSOA000899b

Summary for 7GTB

Entry DOI	10.2210/pdb7gtb/pdb
Group deposition	PanDDA Analysis group deposition (G_1002284)
Descriptor	Tyrosine-protein phosphatase non-receptor type 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 1H-indole-5-carboxylic acid, ... (4 entities in total)
Functional Keywords	pandda, diamond i04-1 fragment screening, protein tyrosine phosphatase, ptp, protein tyrosine phosphatase 1b, ptp1b, enzyme, allostery, multiconformer, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	37628.86
Authors	Mehlman, T.,Ginn, H.M.,Keedy, D.A. (deposition date: 2024-01-03, release date: 2024-01-24, Last modification date: 2024-04-24)
Primary citation	Mehlman, T.S.,Ginn, H.M.,Keedy, D.A. An expanded view of ligandability in the allosteric enzyme PTP1B from computational reanalysis of large-scale crystallographic data. Biorxiv, 2024 Cited by PubMed: 38260327 DOI: 10.1101/2024.01.05.574428 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.86 Å)

Structure validation