7GS3

Crystal structure of SARS-CoV-2 main protease in complex with cpd-26

7GS3 の概要

• エントリーDOI: 10.2210/pdb7gs3/pdb
• Group deposition: Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket (G_1002282)
• 分子名称: 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, (6-phenylpyridin-3-yl)methanamine, ... (5 entities in total)
• 機能のキーワード: protease, sars-cov-2, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68248.99

構造登録者

Huang, C.-Y.,Metz, A.,Sharpe, M.,Sweeney, A. (登録日: 2023-11-14, 公開日: 2024-02-14, 最終更新日: 2024-03-13)

• 主引用文献: Huang, C.Y.,Metz, A.,Lange, R.,Artico, N.,Potot, C.,Hazemann, J.,Muller, M.,Dos Santos, M.,Chambovey, A.,Ritz, D.,Eris, D.,Meyer, S.,Bourquin, G.,Sharpe, M.,Mac Sweeney, A.; Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket.; Acta Crystallogr D Struct Biol, 80:123-136, 2024; PubMed: 38289714; DOI: 10.1107/S2059798324000329

実験手法

X-RAY DIFFRACTION (1.89 Å)