7FWQ

Crystal Structure of human FABP4 binding site mutated to that of FABP3 in complex with 6-chloro-4-(2-chlorophenoxy)-2-methylquinoline-3-carboxylic acid, i.e. SMILES c1(ccc2c(c1)c(c(c(n2)C)C(=O)O)Oc1c(cccc1)Cl)Cl with IC50=0.048 microM

Summary for 7FWQ

• Entry DOI: 10.2210/pdb7fwq/pdb
• Group deposition: To be published (G_1002264)
• Descriptor: Fatty acid-binding protein, adipocyte, 6-chloro-4-(2-chlorophenoxy)-2-methylquinoline-3-carboxylic acid, DIMETHYL SULFOXIDE, ... (5 entities in total)
• Functional Keywords: lipid binding protein, fatty acid binding protein, cytoplasm, lipid-binding, transport, protein binding
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 15582.62

Authors

Ehler, A.,Benz, J.,Obst, U.,Conte, A.,Rudolph, M.G. (deposition date: 2023-04-27, release date: 2023-06-14, Last modification date: 2024-11-20)

• Primary citation: Obst, U.,Magnone, C.,Kuhn, B.,Rudolph, M.G.; Crystal Structure of a human FABP4 binding site mutated to that of FABP3 complex; To be published,

Experimental method

X-RAY DIFFRACTION (1.2 Å)