7FWM

Crystal Structure of human FABP4 binding site mutated to that of FABP3 in complex with 1-[(4-chloro-2-phenylphenyl)methyl]-4-hydroxypyridin-2-one, i.e. SMILES C1(=CC(=O)N(C=C1)Cc1ccc(cc1c1ccccc1)Cl)O with IC50=2.3 microM

7FWM の概要

• エントリーDOI: 10.2210/pdb7fwm/pdb
• Group deposition: To be published (G_1002264)
• 分子名称: Fatty acid-binding protein, adipocyte, 1-[(5-chloro[1,1'-biphenyl]-2-yl)methyl]-4-hydroxy-5,6-dihydropyridin-2(1H)-one, DIMETHYL SULFOXIDE, ... (4 entities in total)
• 機能のキーワード: lipid binding protein, fatty acid binding protein, cytoplasm, lipid-binding, transport, protein binding
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15452.15

構造登録者

Ehler, A.,Benz, J.,Obst, U.,Obst-Sander, U.,Rudolph, M.G. (登録日: 2023-04-27, 公開日: 2023-06-14, 最終更新日: 2024-11-20)

• 主引用文献: Obst, U.,Magnone, C.,Kuhn, B.,Rudolph, M.G.; Crystal Structure of a human FABP4 binding site mutated to that of FABP3 complex; To be published,

実験手法

X-RAY DIFFRACTION (1.17 Å)