7FVT

Crystal Structure of S. aureus gyrase in complex with 6-[5-[2-[(4-chloro-2,3-dihydro-1H-inden-2-yl)methylamino]ethyl]-2-oxo-1,3-oxazolidin-3-yl]-4H-pyrido[3,2-b][1,4]oxazin-3-one

Summary for 7FVT

• Entry DOI: 10.2210/pdb7fvt/pdb
• Group deposition: A set of S. aureus gyrase BA fusion crystal structures (G_1002266)
• Descriptor: DNA gyrase subunit B,DNA gyrase subunit A Chimera, DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3'), MANGANESE (II) ION, ... (6 entities in total)
• Functional Keywords: dna gyrase, topoisomerase;, isomerase
• Biological source: Staphylococcus aureus subsp. aureus N315; More
• Total number of polymer chains: 4
• Total formula weight: 169203.98

Authors

Xu, B.,Benz, J.,Cumming, J.G.,Rudolph, M.G. (deposition date: 2023-04-18, release date: 2023-06-28, Last modification date: 2023-08-16)

• Primary citation: Cumming, J.G.,Kreis, L.,Kuhne, H.,Wermuth, R.,Vercruysse, M.,Kramer, C.,Rudolph, M.G.,Xu, Z.; Discovery of a Series of Indane-Containing NBTIs with Activity against Multidrug-Resistant Gram-Negative Pathogens.; Acs Med.Chem.Lett., 14:993-998, 2023; PubMed: 37465290; DOI: 10.1021/acsmedchemlett.3c00187

Experimental method

X-RAY DIFFRACTION (2.081 Å)