7FVS

Crystal Structure of S. aureus gyrase in complex with 4-[[1-[(1-chloro-6,7-dihydro-5H-cyclopenta[c]pyridin-6-yl)methyl]azetidin-3-yl]methylamino]-6-fluorochromen-2-one

7FVS の概要

• エントリーDOI: 10.2210/pdb7fvs/pdb
• Group deposition: A set of S. aureus gyrase BA fusion crystal structures (G_1002266)
• 分子名称: DNA gyrase subunit B,DNA gyrase subunit A Chimera, DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3'), MANGANESE (II) ION, ... (7 entities in total)
• 機能のキーワード: dna gyrase, topoisomerase;, isomerase
• 由来する生物種: Staphylococcus aureus subsp. aureus N315; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 169163.09

構造登録者

Xu, B.,Benz, J.,Cumming, J.G.,Kreis, L.,Rudolph, M.G. (登録日: 2023-04-18, 公開日: 2023-06-28, 最終更新日: 2023-08-16)

• 主引用文献: Cumming, J.G.,Kreis, L.,Kuhne, H.,Wermuth, R.,Vercruysse, M.,Kramer, C.,Rudolph, M.G.,Xu, Z.; Discovery of a Series of Indane-Containing NBTIs with Activity against Multidrug-Resistant Gram-Negative Pathogens.; Acs Med.Chem.Lett., 14:993-998, 2023; PubMed: 37465290; DOI: 10.1021/acsmedchemlett.3c00187

実験手法

X-RAY DIFFRACTION (2.16 Å)