7FUG

Crystal Structure of human cyclic GMP-AMP synthase in complex with 5-benzyl-2-[[2-chloro-5-(1-methylpyrazol-3-yl)phenyl]methylamino]-4H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one

Summary for 7FUG

• Entry DOI: 10.2210/pdb7fug/pdb
• Group deposition: To be published (G_1002263)
• Descriptor: Cyclic GMP-AMP synthase, ZINC ION, (8S)-5-benzyl-2-({[(5P)-2-chloro-5-(1-methyl-1H-pyrazol-3-yl)phenyl]methyl}amino)[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one, ... (4 entities in total)
• Functional Keywords: immune response, transferase, ntase, dna sensor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 85832.44

Authors

Leibrock, L.,Benz, J.,Groebke-Zbinden, K.,Rudolph, M.G. (deposition date: 2023-02-08, release date: 2024-02-21)

• Primary citation: Groebke-Zbinden, K.,Vandemeulebroucke, A.,Hilbert, M.,Rudolph, M.G.; Crystal Structure of a human cyclic GMP-AMP synthase complex; To be published,

Experimental method

X-RAY DIFFRACTION (2.106 Å)